Concordance between predicted HLA type using next generation sequencing data generated for non-HLA purposes and clinical HLA type

We explored the feasibility of obtaining accurate HLA type using pre-existing NGS data not generated for HLA purposes. 83 exomes and 500 targeted NGS pharmacogenomic panels were analyzed using Omixon HLA Explore, OptiType, and/or HLA-Genotyper software. Results were compared against clinical HLA gen...

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Veröffentlicht in:Hum Immunol
Hauptverfasser: Moyer, Ann M., Dukek, Brian, Duellman, Patti, Schneider, Brittany, Wakefield, Laurie, Skierka, Jennifer M., Avula, Rajeswari, Bhagwate, Aditya V., Kalari, Krishna R., Kreuter, Justin D., Goetz, Matthew P., Boughey, Judy C., Black, John L., Gandhi, Manish J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721171/
https://ncbi.nlm.nih.gov/pubmed/32546429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2020.06.002
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