HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

OBJECTIVE: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation. The aim of the present study was to develop an...

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Publicado no:Cancer Biol Med
Principais autores: Zeng, Wu, Kwan Law, Betty Yuen, Wai Wong, Vincent Kam, Bik Chan, Denise So, Fai Mok, Simon Wing, Ying Gao, Joyce Jia, Yan Ho, Rebecca Ka, Liang, Xu, Li, Jia Hao, Lee, Ming Tsung, Yoon, Weng Li, Smolinski, Michael P, Nam Lau, Johnson Yiu, Kei Lam, Christopher Wai, Fok, Manson
Formato: Artigo
Idioma:Inglês
Publicado em: Compuscript 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721091/
https://ncbi.nlm.nih.gov/pubmed/33299648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2020.0128
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