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Acute Alcohol Intoxication Impairs Sonic Hedgehog-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia

BACKGROUND: Activation of hematopoietic stem cells [HSCs, lineage(lin)(−)stem cell growth factor receptor (c-kit)(+)stem cell antigen-1(Sca-1)(+), or LKS cells in mice] is critical for initiating the granulopoietic response. This study determined the effect of alcohol exposure on sonic hedgehog (SHH...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Alcohol Clin Exp Res
Päätekijät: Shi, Xin, Simms, Kevin J., Zhang, Ping
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720280/
https://ncbi.nlm.nih.gov/pubmed/32772391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.14429
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