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A microbial metabolite synergizes with endogenous serotonin to trigger C. elegans reproductive behavior

Natural products are a major source of small-molecule therapeutics, including those that target the nervous system. We have used a simple serotonin-dependent behavior of the roundworm Caenorhabditis elegans, egg laying, to perform a behavior-based screen for natural products that affect serotonin si...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chen, Yen-Chih, Seyedsayamdost, Mohammad R., Ringstad, Niels
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720207/
https://ncbi.nlm.nih.gov/pubmed/33199611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017918117
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