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Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin

Polycomb repressive complex 2 (PRC2) installs and spreads repressive histone methylation marks on eukaryotic chromosomes. Because of the key roles that PRC2 plays in development and disease, how this epigenetic machinery interacts with DNA and nucleosomes is of major interest. Nonetheless, the mecha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Leicher, Rachel, Ge, Eva J., Lin, Xingcheng, Reynolds, Matthew J., Xie, Wenjun, Walz, Thomas, Zhang, Bin, Muir, Tom W., Liu, Shixin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720148/
https://ncbi.nlm.nih.gov/pubmed/33208532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003395117
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