The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses

The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functional genetic interaction between proteins from inf...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Weston, Stuart, Baracco, Lauren, Keller, Chloe, Matthews, Krystal, McGrath, Marisa E., Logue, James, Liang, Janie, Dyall, Julie, Holbrook, Michael R., Hensley, Lisa E., Jahrling, Peter B., Yu, Wenbo, MacKerell, Alexander D., Frieman, Matthew B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720140/
https://ncbi.nlm.nih.gov/pubmed/33184176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012939117
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