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Computational Polypharmacology Analysis of the Heat Shock Protein 90 Interactome

The design of a single drug molecule that is able to simultaneously and specifically interact with multiple biological targets is gaining major consideration in drug discovery. However, the rational design of drugs with a desired polypharmacology profile is still a challenging task, especially when...

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Detalles Bibliográficos
Publicado en:J Chem Inf Model
Autores principales: Anighoro, Andrew, Stumpfe, Dagmar, Heikamp, Kathrin, Beebe, Kristin, Neckers, Leonard M., Bajorath, Jürgen, Rastelli, Giulio
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720080/
https://ncbi.nlm.nih.gov/pubmed/25686391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci5006959
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