HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model

Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase of regulatory T cells contribute to an immunosuppressive tumor microenvironment. As a result, CLL patients are severely susceptible to infec...

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發表在:Front Immunol
Main Authors: Maharaj, Kamira, Powers, John J., Mediavilla-Varela, Melanie, Achille, Alex, Gamal, Wael, Quayle, Steven, Jones, Simon S., Sahakian, Eva, Pinilla-Ibarz, Javier
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719839/
https://ncbi.nlm.nih.gov/pubmed/33329575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.590072
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