Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, a novel cell death form, contributes to inflammation-induced neuron death and neurological function impairment following ischemic stroke. Gasdermin D...

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Publicat a:Front Neurol
Autors principals: Wang, Kankai, Sun, Zhezhe, Ru, Junnan, Wang, Simin, Huang, Lijie, Ruan, Linhui, Lin, Xiao, Jin, Kunlin, Zhuge, Qichuan, Yang, Su
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Neurology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719685/
https://ncbi.nlm.nih.gov/pubmed/33329317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.577927
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