First Clinical Study with AP30663 ‐ a K(Ca)2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

Pharmacological cardioversion of atrial fibrillation (AF) is frequently inefficacious. AP30663, a small conductance Ca(2+) activated K(+) (K(Ca)2) channel blocker, prolonged the atrial effective refractory period in preclinical studies and subsequently converted AF into normal sinus rhythm. This fir...

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Gepubliceerd in:Clin Transl Sci
Hoofdauteurs: Gal, Pim, Klaassen, Erica S., Bergmann, Kirsten R., Saghari, Mahdi, Burggraaf, Jacobus, Kemme, Michiel J. B., Sylvest, Christina, Sørensen, Ulrik, Bentzen, Bo H., Grunnet, Morten, Diness, Jonas G., Edvardsson, Nils
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719388/
https://ncbi.nlm.nih.gov/pubmed/32725783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12835
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