HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma

Pyruvate kinase M2 (PKM2) is not only a key rate-limiting enzyme that guides glycolysis, but also acts as a non-metabolic protein in regulating gene transcription. In recent years, a series of studies have confirmed that post-translational modification has become an important mechanism for regulatin...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Zhang, Ruixue, Shen, Mengqin, Wu, Chunhua, Chen, Yumei, Lu, Jiani, Li, Jiajin, Zhao, Li, Meng, Huannan, Zhou, Xiang, Huang, Gang, Zhao, Xiaoping, Liu, Jianjun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719180/
https://ncbi.nlm.nih.gov/pubmed/33279948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03212-3
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