The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice

Alcohol-associated liver disease is accompanied by dysregulation of bile acid metabolism and gut barrier dysfunction. Peroxisome proliferator-activated receptor-delta (PPARδ) agonists are key metabolic regulators and have anti-inflammatory properties. Here, we evaluated the effect of the selective P...

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Gepubliceerd in:Transl Res
Hoofdauteurs: CHU, HUIKUAN, JIANG, LU, GAO, BEI, GAUTAM, NAGSEN, ALAMOUDI, JAWAHER A., LANG, SONJA, WANG, YANHAN, DUAN, YI, ALNOUTI, YAZEN, CABLE, EDWARD E., SCHNABL, BERND
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719076/
https://ncbi.nlm.nih.gov/pubmed/32553670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2020.06.006
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