Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation

PURPOSE: The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug. METHODS: Central design composite was adopted for the formulation and optimization of table...

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Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Moin, Afrasim, Gangadharappa, Hosahalli V, Adnan, Mohd, Rizvi, Syed M, Ashraf, Syed A, Patel, Mitesh, Abu Lila, Amr S, Allam, Ahmed N
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7719052/
https://ncbi.nlm.nih.gov/pubmed/33293794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S279955
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