Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma

Up-regulation of Uridine-cytidine kinase 2 (UCK2), a rate-limiting enzyme of the pyrimidine salvage pathway, has been suggested in HCC, but the detailed molecular mechanisms and therapic role of UCK2 remain elusive. Bioinformatic analyses revealed that UCK2 might be a key up-regulated metabolic gene...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Cai, Jie, Sun, Xuehua, Guo, Han, Qu, Xiaoye, Huang, Hongting, Yu, Chang, Wu, Hailong, Gao, Yueqiu, Kong, Xiaoni, Xia, Qiang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718876/
https://ncbi.nlm.nih.gov/pubmed/33277463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00287-7
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