Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma

Up-regulation of Uridine-cytidine kinase 2 (UCK2), a rate-limiting enzyme of the pyrimidine salvage pathway, has been suggested in HCC, but the detailed molecular mechanisms and therapic role of UCK2 remain elusive. Bioinformatic analyses revealed that UCK2 might be a key up-regulated metabolic gene...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Cai, Jie, Sun, Xuehua, Guo, Han, Qu, Xiaoye, Huang, Hongting, Yu, Chang, Wu, Hailong, Gao, Yueqiu, Kong, Xiaoni, Xia, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718876/
https://ncbi.nlm.nih.gov/pubmed/33277463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00287-7
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