Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice

AIMS/HYPOTHESIS: Melanocortin 4 receptor (MC4R) mutation is the most common cause of known monogenic obesity in humans. Unexpectedly, humans and rodents with MC4R deficiency do not develop hyperglycaemia despite chronic obesity and insulin resistance. To explain the underlying mechanisms for this ph...

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Bibliografske podrobnosti
izdano v:Diabetologia
Main Authors: de Souza Cordeiro, Leticia Maria, Elsheikh, Arwa, Devisetty, Nagavardhini, Morgan, Donald A., Ebert, Steven N., Rahmouni, Kamal, Chhabra, Kavaljit H.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718429/
https://ncbi.nlm.nih.gov/pubmed/33052459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05289-z
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