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Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
De novo formation of the double-membrane compartment autophagosome is seeded by small vesicles carrying membrane protein autophagy-related 9 (ATG9), whose function remains unknown. Here we find that ATG9A scrambles phospholipids of membranes in vitro. Cryo-EM structures of human ATG9A reveal a trime...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7718406/ https://ncbi.nlm.nih.gov/pubmed/33106659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00520-2 |
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