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Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

Autophagy is an enigmatic cellular process in which double-membrane compartments, called “autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and package cytoplasmic contents for delivery to lysosomes. Expansion of the precursor membrane phagophore requires autophagy-related 2 (A...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chowdhury, Saikat, Otomo, Chinatsu, Leitner, Alexander, Ohashi, Kazuto, Aebersold, Ruedi, Lander, Gabriel C., Otomo, Takanori
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196511/
https://ncbi.nlm.nih.gov/pubmed/30185561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811874115
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