S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer

The development of resistance to EGFR Tyrosine kinase inhibitors (TKIs) in NSCLC with activating EGFR mutations is a critical limitation of this therapy. In addition to genetic alterations such as EGFR secondary mutation causing EGFR-TKI resistance, compensatory activation of signaling pathways with...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Shen, Hua, Wang, Gao-Chan, Li, Xiang, Ge, Xin, Wang, Meng, Shi, Zhu-Mei, Bhardwaj, Vikas, Wang, Zi-Xuan, Zinner, Ralph G., Peiper, Stephen C., Aplin, Andrew E., Jiang, Bing-Hua, He, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718330/
https://ncbi.nlm.nih.gov/pubmed/33037411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01497-4
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