An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients

Insulin has been used to treat diabetes for almost 100 years, yet current rapid-acting insulin formulations do not have sufficiently fast pharmacokinetics to maintain tight glycemic control at mealtimes. Dissociation of the insulin hexamer, the primary association state of insulin in rapid-acting fo...

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Vydáno v:Sci Transl Med
Hlavní autoři: Mann, Joseph L., Maikawa, Caitlin L., Smith, Anton A. A., Grosskopf, Abigail K., Baker, Sam W., Roth, Gillie A., Meis, Catherine M., Gale, Emily C., Liong, Celine S., Correa, Santiago, Chan, Doreen, Stapleton, Lyndsay M., Yu, Anthony C., Muir, Ben, Howard, Shaun, Postma, Almar, Appel, Eric A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716884/
https://ncbi.nlm.nih.gov/pubmed/32611683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aba6676
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