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Klotho attenuates angiotensin II-induced cardiotoxicity through suppression of necroptosis and oxidative stress
Hyperglycemia is known to lead to cardiac injury and inflammation through the reactive oxygen species (ROS)-Toll-like receptor 4 (TLR4)-necroptosis pathway. Similarly, angiotensin II (Ang II) activates the TLR4-nuclear factor κB (NF-κB) p65 pathway, while the protein Klotho is known to inhibit this...
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| Publicado en: | Mol Med Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
D.A. Spandidos
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7716407/ https://ncbi.nlm.nih.gov/pubmed/33215215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11705 |
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