Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells

Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all-trans retinoic acid (ATRA) an...

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Détails bibliographiques
Publié dans:Cells
Auteurs principaux: Albanesi, Jacopo, Noguera, Nelida Ines, Banella, Cristina, Colangelo, Tommaso, De Marinis, Elisabetta, Leone, Stefano, Palumbo, Orazio, Voso, Maria Teresa, Ascenzi, Paolo, Nervi, Clara, Bianchi, Fabrizio, di Masi, Alessandra
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716236/
https://ncbi.nlm.nih.gov/pubmed/33167477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112423
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