DDEL-10. A NANOPARTICLE PLATFORM FOR INTRATHECAL DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR (HDACi) PANOBINOSTAT IN METASTATIC OR RECURRENT MEDULLOBLASTOMA

INTRODUCTION: Panobinostat is a histone deacetylase inhibitor (HDACi) that is a clinical candidate for treatment of pediatric medulloblastoma and diffuse intrinsic pontine glioma. Panobinostat is poorly water-soluble and experiences a number of barriers to effective delivery. Here, we developed a no...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chaudhuri, Sauradip, Mohammad, Afroz S, Zhang, Wenqui, Baker, Cassandra, Broughton, Colton W, Fowler, Martha J, Stabenfeldt, Sarah E, Wechsler-Reya, Robert J, Sandberg, David I, Elmquist, William F, Sirianni, Rachael W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Delivery/Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715872/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.045
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