EPCT-11. PHASE 1 STUDY OF FLUVASTATIN-CELECOXIB COMBINATION IN CHILDREN WITH RELAPSING/REFRACTORY OPTICO-CHIASMATIC LOW-GRADE GLIOMA OR HIGH-GRADE GLIOMAS (FLUVABREX): FINAL RESULTS

BACKGROUND: Preclinical data support the activity of celecoxib and fluvastatin in high grade (HGG) and low grade gliomas (LGG). A Phase I study was designed to evaluate this combination in children with refractory/relapsed glioma. AIM: To assess the safety, pharmacokinetics (PK), maximum tolerated d...

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Vydáno v:Neuro Oncol
Hlavní autoři: Andrew, Nicolas, Sterin, Arthur, Solas, Caroline, Deley, Marie-Cécile Le, Probst, Alicia, Aerts, Isabelle, Faure-Conter, Cécile, Bertozzi, Anne-Isabelle, Chastagner, Pascal, Entz-Werle, Natacha, De Carli, Emilie, Dory-Lautrec, Philippe, Bouche, Gauthier, Leblond, Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Early Phase Clinical Trials
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715843/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.134
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