LGG-50. INTEGRATED MOLECULAR AND CLINICAL ANALYSIS OF 1,000 PEDIATRIC LOW-GRADE GLIOMAS UNCOVERS NOVEL SUBGROUPS FOR CLINICAL RISK STRATIFICATION

Pediatric low-grade gliomas (pLGG) are primarily driven by genetic alterations in the RAS/MAPK pathway, most commonly involving BRAF of NF1. Despite their molecular convergence, pLGG often show unexplained variability in their clinical outcome. To address this, we molecularly characterized a cohort...

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發表在:Neuro Oncol
Main Authors: Tabori, Uri, Ryall, Scott, Zapotocky, Michal, Bennett, Julie, Nobre, Liana, Ellison, David, Santi, Mariarita, Karajannis, Matthias, Hawkins, Cynthia
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Low Grade Glioma
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715842/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.428
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