MODL-24. AN ORGANOTYPIC CHUNK CULTURE TECHNIQUE TO STUDY DISEASE MECHANISM AND DEVELOP TARGETED THERAPEUTICS FOR PEDIATRIC ADAMANTINOMATOUS CRANIOPHARYNGIOMA

BACKGROUND: Advances in the treatment of Adamantinomatous Craniopharyngioma (ACP) face challenges with translation to clinical study due to the absence of robust culture models of the disease. We developed a technique for culturing human ACP tissue in an organotypic chunk culture format that retains...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Vijmasi, Trinka, Prince, Eric, Hengartner, Astrid, Staulcup, Susan, Griesinger, Andrea, Donson, Andrew, Gilani, Ahmed, Foreman, Nicholas, Hankinson, Todd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Preclinical Models/Experimental Therapy/Drug Discovery
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715791/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.597
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