MODL-02. TARGETING REPLICATION STRESS IN PEDIATRIC BRAIN TUMORS

Pediatric brain tumors harboring amplifications or high overexpression of MYC-/MYCN are often associated with poor outcome. High MYC(N) expression in these tumors leads to increased transcription, which can be in conflict with DNA replication and subsequently can cause replication stress, R-loops an...

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Publicat a:Neuro Oncol
Autors principals: Krausert, Sonja, Lambo, Sander, Mack, Norman, Schwalm, Benjamin, Pfister, Stefan, Kool, Marcel
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Preclinical Models/Experimental Therapy/Drug Discovery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715544/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.579
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