EPEN-33. PHARMACOGENOMICS REVEALS SYNERGISTIC INHIBITION OF ERBB2 AND PI3K SIGNALING AS A THERAPEUTIC STRATEGY FOR EPENDYMOMA

Subgroups of ependymoma, especially RELA fusion-positive and posterior fossa type A tumors, are associated with poor prognosis. Curative therapeutic strategies have not yet been identified. We set up a high-throughput drug screening (HTS) pipeline to evaluate clinically established compounds (n=196)...

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Foilsithe in:Neuro Oncol
Main Authors: Pauck, David, Paisana, Eunice, Cascão, Rita, Sarikaya-Seiwert, Sevgi, Marquardt, Viktoria, Picard, Daniel, Bartl, Jasmin, Blümel, Lena, Maue, Mara, Dimitriadis, Christian, Taban, Kübra, Fischer, Ute, Steiger, Hans Jakob, Faria, Cláudia, Reifenberger, Guido, Borkhardt, Arndt, Beez, Thomas, Remke, Marc
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Ependymoma
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715461/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.168
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