EPCT-02. PBTC-051: FIRST IN PEDIATRICS PHASE 1 STUDY OF CD40 AGONISTIC MONOCLONAL ANTIBODY APX005M IN PEDIATRIC SUBJECTS WITH RECURRENT/REFRACTORY BRAIN TUMORS

BACKGROUND: CD40 is a co-stimulatory molecule expressed on antigen presenting cells (APCs). APX005M is a CD40 agonist monoclonal antibody which stimulates innate and adaptive anti-tumor immunity through activation of APCs, macrophages, and antigen-specific CD8(+)T-cells. Pediatric Brain Tumor Consor...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lindsay, Holly, Onar-Thomas, Arzu, Kocak, Mehmet, Poussaint, Tina Young, Dhall, Girish, Broniscer, Alberto, Vinitsky, Anna, MacDonald, Tobey, Trifan, Ovid, Fangusaro, Jason, Dunkel, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Early Phase Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715375/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.127
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