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TBIO-14. CHARACTERISATION OF THE ARGININE PATHWAY ENZYMES IN PAEDIATRIC BRAIN TUMOURS TO DETERMINE SUSCEPTIBILITY TO THERAPEUTIC ARGININE DEPLETION

INTRODUCTION: Extracellular arginine dependency (auxotrophy) is increasingly being recognised in several tumours. This is due to the inability of cancer cells to recycle or synthesise intracellular arginine through the urea cycle pathway compared to normal cells. Whilst adult glioblastoma is known t...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Bishop, Eleanor, Dimitrova, Monika, Storer, Lisa, Grundy, Richard, Dandapani, Madhumita
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715343/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.841
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