ATRT-16. MODELLING ATRT THROUGH SWI/SNF COMPLEX DEFICIENCY IN GENETICALLY-ENGINEERED MOUSE MODELS

Atypical Teratoid/Rhabdoid Tumours (ATRT) are highly malignant neoplasms arising primarily in the CNS of children. They are defined by loss of function mutations in smarcb1, a gene serving a vital role in neurogenesis and differentiation. In order to recapitulate ATRT in the mouse, we used a Cre-Lox...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Bondoc, Andrew, Golbourn, Brian, Smith, Christian, Huang, Annie, Rutka, James
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Atypical Teratoid/Rhabdoid Tumors
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715131/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.015
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