EPCT-15. THE REMIND TRIAL: MULTI-ANTIGEN TARGETED T CELLS FOR PEDIATRIC CNS TUMORS

BACKGROUND: Patients with relapsed CNS malignancies or DIPG face terrible prognoses. We hypothesized that T cells specific for 3 tumor-associated antigens (TAA), WT1, PRAME and survivin, would be safe and elicit anti-tumor immunity. METHODS: Patients (n=9) have received autologous tumor antigen-asso...

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Foilsithe in:Neuro Oncol
Main Authors: Grant, Melanie, Fortiz, Maria Fernanda, Wang, Lu, Lang, Haili, Datar, Anushree, Reynolds, Emily, Terpilowski, Madeline, Lazarski, Chris, Tanna, Jay, Pitino, Adriana, Zhang, Nan, Hoq, Fahmida, Hanley, Patrick, Kilburn, Lindsay, Packer, Roger, Rood, Brian, Bollard, Catherine, Hwang, Eugene
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Early Phase Clinical Trials
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715090/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.137
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