microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production

Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects cholesterol homeostasis by targeting hepatic LDL receptor (LDLR) for lysosomal degradation. Clinically, PCSK9 inhibitors effectively reduce LDL-cholesterol (LDL-C) levels and the incidence of cardiovascular events. Because microRNAs (miRs...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Dong, Jianjie, He, Ming, Li, Jie, Pessentheiner, Ariane, Wang, Chen, Zhang, Jin, Sun, Yameng, Wang, Wei-Ting, Zhang, Yuqing, Liu, Junhui, Wang, Shen-Chih, Huang, Po-Hsun, Gordts, Philip L.S.M., Yuan, Zu-Yi, Tsimikas, Sotirios, Shyy, John Y.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714402/
https://ncbi.nlm.nih.gov/pubmed/33119548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143812
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