BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

The resistance of synovial sublining macrophages to apoptosis has a crucial role in joint inflammation and destruction in rheumatoid arthritis (RA). However, the underlying mechanism is incompletely understood. Here we report that inactivation of the pro-apoptotic BCL-2 family protein BAD is essenti...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Li, Jie, Zhang, Liansheng, Zheng, Yongwei, Shao, Rui, Liang, Qianqian, Yu, Weida, Wang, Hongyan, Zou, Weiguo, Wang, Demin, Xiang, Jialing, Lin, Anning
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714394/
https://ncbi.nlm.nih.gov/pubmed/33270017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56309
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