Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression

Sepsis is characterized by a dysregulated immune response, metabolic derangements and bioenergetic failure. These alterations are closely associated with a profound and persisting mitochondrial dysfunction. This however occurs despite increased expression of the nuclear-encoded transcription factor...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rahmel, Tim, Marko, Britta, Nowak, Hartmuth, Bergmann, Lars, Thon, Patrick, Rump, Katharina, Kreimendahl, Sebastian, Rassow, Joachim, Peters, Jürgen, Singer, Mervyn, Adamzik, Michael, Koos, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713186/
https://ncbi.nlm.nih.gov/pubmed/33273525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78195-4
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