LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1...

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Udgivet i:Cells
Main Authors: Koos, Björn, Moderegger, Eva Lotta, Rump, Katharina, Nowak, Hartmuth, Willemsen, Katrin, Holtkamp, Caroline, Thon, Patrick, Adamzik, Michael, Rahmel, Tim
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650703/
https://ncbi.nlm.nih.gov/pubmed/33066217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102282
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