LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Koos, Björn, Moderegger, Eva Lotta, Rump, Katharina, Nowak, Hartmuth, Willemsen, Katrin, Holtkamp, Caroline, Thon, Patrick, Adamzik, Michael, Rahmel, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650703/
https://ncbi.nlm.nih.gov/pubmed/33066217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102282
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