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Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis

Hepatic fibrogenesis is characterized by activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix (ECM). The impact of ECM on TGF-β-mediated fibrogenic signaling pathway in HSCs has remained obscure. We studied the role of non-receptor tyrosine kinase focal adhesion kinas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kim, Jonghwa, Kang, Wonseok, Kang, So Hee, Park, Su Hyun, Kim, Ji Young, Yang, Sera, Ha, Sang Yun, Paik, Yong-Han
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713048/
https://ncbi.nlm.nih.gov/pubmed/33273492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78056-0
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