Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis

Hepatic fibrogenesis is characterized by activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix (ECM). The impact of ECM on TGF-β-mediated fibrogenic signaling pathway in HSCs has remained obscure. We studied the role of non-receptor tyrosine kinase focal adhesion kinas...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Kim, Jonghwa, Kang, Wonseok, Kang, So Hee, Park, Su Hyun, Kim, Ji Young, Yang, Sera, Ha, Sang Yun, Paik, Yong-Han
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713048/
https://ncbi.nlm.nih.gov/pubmed/33273492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78056-0
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