A Novel Nomenclature for Repeat Motifs in the Thymidylate Synthase Enhancer Region and Its Relevance for Pharmacogenetic Studies

Inhibition of thymidylate synthase (TS) is the primary mode of action for 5-fluorouracil (5FU) chemotherapy. TS expression is modulated by a variable number of tandem repeats in the TS enhancer region (TSER) located upstream of the TS gene (TYMS). Variability in the TSER has been suggested to contri...

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Vydáno v:J Pers Med
Hlavní autoři: Schaerer, Dominic, Froehlich, Tanja K., Hamzic, Seid, Offer, Steven M., Diasio, Robert B., Joerger, Markus, Amstutz, Ursula, Largiadèr, Carlo R.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7712088/
https://ncbi.nlm.nih.gov/pubmed/33086767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm10040181
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