Podophyllotoxin Exposure Causes Spindle Defects and DNA Damage-Induced Apoptosis in Mouse Fertilized Oocytes and Early Embryos

Podophyllotoxin (PPT) is a kind of lignans extracted from the roots and stems of the genus Podophyllum from the tiller family, and it has been widely used in the treatment of condyloma acuminatum, multiple superficial epithelioma in the clinics. However, PPT has been reported to be toxic and can cau...

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Опубликовано в: :Front Cell Dev Biol
Главные авторы: Hu, Lin-Lin, Liao, Bi-Yun, Wei, Jing-Xi, Ling, Yan-Lan, Wei, Yu-Xia, Liu, Zhong-Lin, Luo, Xiao-Qiong, Wang, Jun-Li
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710938/
https://ncbi.nlm.nih.gov/pubmed/33330491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.600521
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