Podophyllotoxin Exposure Causes Spindle Defects and DNA Damage-Induced Apoptosis in Mouse Fertilized Oocytes and Early Embryos

Podophyllotoxin (PPT) is a kind of lignans extracted from the roots and stems of the genus Podophyllum from the tiller family, and it has been widely used in the treatment of condyloma acuminatum, multiple superficial epithelioma in the clinics. However, PPT has been reported to be toxic and can cau...

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Publicat a:Front Cell Dev Biol
Autors principals: Hu, Lin-Lin, Liao, Bi-Yun, Wei, Jing-Xi, Ling, Yan-Lan, Wei, Yu-Xia, Liu, Zhong-Lin, Luo, Xiao-Qiong, Wang, Jun-Li
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710938/
https://ncbi.nlm.nih.gov/pubmed/33330491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.600521
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