FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our previous study found FBW7 was low expressed in pancreatic cancer due to sustained activation of Ras-Raf-MEK-ERK pathway, which destabilized FBW7 by phosphorylating at Thr205. MicroPET/CT imaging results revealed that...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Ye, Zeng, Zhuo, Qifeng, Hu, Qiangsheng, Xu, Xiaowu, Mengqi liu, Zhang, Zheng, Xu, Wenyan, Liu, Wensheng, Fan, Guixiong, Qin, Yi, Yu, Xianjun, Ji, Shunrong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710650/
https://ncbi.nlm.nih.gov/pubmed/33271455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101807
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