Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Activating mutations in RAS GTPases drive many cancers, but limited understanding of less-studied RAS interactors, and of the specific roles of different RAS interactor paralogs, continues to limit target discovery. We developed a multistage discovery and screening process to systematically identify...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Kelly, Marcus R., Kostyrko, Kaja, Han, Kyuho, Mooney, Nancie A., Jeng, Edwin E., Spees, Kaitlyn, Dinh, Phuong T., Abbott, Keene L., Gwinn, Dana M., Sweet-Cordero, E. Alejandro, Bassik, Michael C., Jackson, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710624/
https://ncbi.nlm.nih.gov/pubmed/32727735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1274
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