BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects

Repair and reconstruction of critical-sized bone defects has always been a difficult task in orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role in bone defect repair, it has the dual function of promoting osteogenesis and vascular regeneration, but it is quickly degraded by th...

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Foilsithe in:Front Bioeng Biotechnol
Main Authors: Ying, Chenting, Wang, Rui, Wang, Zhenlin, Tao, Jie, Yin, Wenjing, Zhang, Jieyuan, Yi, Chengqing, Qi, Xin, Han, Dan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Bioengineering and Biotechnology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710518/
https://ncbi.nlm.nih.gov/pubmed/33330411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.565561
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