RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8(+) T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for re...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tullett, Kirsteen M, Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B, Michael, Nicole, Li, Rong, Policheni, Antonia N, Gruber, Emily, Huang, Cheng, Fulcher, Alex J, Danne, Jillian C, Czabotar, Peter E, Wakim, Linda M, Mintern, Justine D, Ramm, Georg, Radford, Kristen J, Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A, Wright, Mark D, Blewitt, Marnie E, Heath, William R, Shortman, Ken, Purcell, Anthony W, Nicola, Nicos A, Zhang, Jian-Guo, Lahoud, Mireille H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710356/
https://ncbi.nlm.nih.gov/pubmed/33264090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63452
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