Targeting CLEC9A delivers antigen to human CD141(+) DC for CD4(+) and CD8(+)T cell recognition

DC-based vaccines that initiate T cell responses are well tolerated and have demonstrated efficacy for tumor immunotherapy, with the potential to be combined with other therapies. Targeting vaccine antigens (Ag) directly to the DCs in vivo is more effective than cell-based therapies in mouse models...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Tullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H., Radford, Kristen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Technical Advance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033826/
https://ncbi.nlm.nih.gov/pubmed/27699265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87102
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