Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury

Evidence for reduced expression of cyclin G associated kinase (GAK) in glomeruli of patients with chronic kidney disease was observed in the Nephroseq human database, and GAK was found to be associated with the decline in kidney function. To examine the role of GAK, a protein that functions to uncoa...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:JCI Insight
المؤلفون الرئيسيون: Tian, Xuefei, Inoue, Kazunori, Zhang, Yan, Wang, Ying, Sperati, C. John, Pedigo, Christopher E., Zhao, Tingting, Yan, Meihua, Groener, Marwin, Moledina, Dennis G., Ebenezer, Karen, Li, Wei, Zhang, Zhenhai, Liebermann, Dan A., Greene, Lois, Greer, Peter, Parikh, Chirag R., Ishibe, Shuta
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2020
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710277/
https://ncbi.nlm.nih.gov/pubmed/33208557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142740
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