Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis

Structural studies of glycoproteins and their complexes provide critical insights into their roles in normal physiology and disease. Most glycoproteins contain N-linked glycosylation, a key post-translation modification that critically affects protein folding and stability and the binding kinetics u...

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Опубликовано в: :Acta Crystallogr D Struct Biol
Главные авторы: Kozak, Sandra, Bloch, Yehudi, De Munck, Steven, Mikula, Aleksandra, Bento, Isabel, Savvides, Savvas N., Meijers, Rob
Формат: Artigo
Язык:Inglês
Опубликовано: International Union of Crystallography 2020
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709199/
https://ncbi.nlm.nih.gov/pubmed/33263330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798320013753
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