Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific

Bispecific molecules are biologically significant, yet their complex structures pose important manufacturing and pharmacokinetic challenges. Nevertheless, owing to similarities with monoclonal antibodies (mAbs), IgG-like bispecifics conceptually align well with conventional expression and manufactur...

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Detalhes bibliográficos
Publicado no:Antibodies (Basel)
Main Authors: Ramasubramanian, Anusuya, Tennyson, Rachel, Magnay, Maureen, Kathuria, Sagar, Travaline, Tara, Jain, Annu, Lord, Dana M., Salemi, Megan, Sullivan, Caitlin, Magnay, Tristan, Hu, Jiali, Bric-Furlong, Eva, Rival, Pierrick, Zhou, Yanfeng, Hoffmann, Dietmar, Brondyk, William, Radošević, Katarina, Chowdhury, Partha S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709125/
https://ncbi.nlm.nih.gov/pubmed/33172091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9040062
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