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Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis

BACKGROUND: Diversity of the CRISPR locus of Mycobacterium tuberculosis complex has been studied since 1997 for molecular epidemiology purposes. By targeting solely the 43 spacers present in the two first sequenced genomes (H37Rv and BCG), it gave a biased idea of CRISPR diversity and ignored divers...

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Veröffentlicht in:BMC Genomics
Hauptverfasser: Refrégier, Guislaine, Sola, Christophe, Guyeux, Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708916/
https://ncbi.nlm.nih.gov/pubmed/33256602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-07178-6
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