Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load <...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Siedner, Mark J., Moorhouse, Michelle A., Simmons, Bryony, de Oliveira, Tulio, Lessells, Richard, Giandhari, Jennifer, Kemp, Stephen A., Chimukangara, Benjamin, Akpomiemie, Godspower, Serenata, Celicia M., Venter, Willem D. F., Hill, Andrew, Gupta, Ravindra K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708638/
https://ncbi.nlm.nih.gov/pubmed/33262331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19801-x
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